pentobarbital will lessen the extent or outcome of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to the lower in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, improvement of the withdra